Oct 29, 2009 (CIDRAP News) – Though only available for emergency use, intravenous (IV) antivirals peramivir and zanamivir have been lifesaving for some pandemic H1N1 patients, including two dramatic cases that doctors presented yesterday during a US Centers for Disease Control and Prevention (CDC) conference call for clinicians.With rising levels of widespread flu activity sweeping the nation, physicians will face greater numbers of critically ill patients, some of whom will require extreme measures, including investigational regimens. Yesterday’s CDC call was designed to get doctors quickly up to speed on the IV antiviral treatment options for the severest pandemic H1N1 infections.The CDC invited two well-known flu experts to discuss the cases and answer clinicians’ questions: Fred Hayden, MD, a virologist at the University of Virginia, and Andrew Pavia, MD, chief of pediatric infectious diseases at the University of Utah.On Oct 23 federal officials issued an emergency use authorization for IV peramivir, to make it easier for physicians to obtain for their severely ill.Though IV zanamivir hasn’t been studied as long as IV peramivir, physicians can request it through the emergency use provision and have used it during the H1N1 pandemic, especially when managing the few oseltamivir-resistant cases that have surfaced.Peramivir after failed oseltamivirIn discussing the first case, Stacene Maroushek, MD, a pediatric infectious disease specialist at Hennepin County Medical Center in Minneapolis, described a 17-year-old boy who was first brought to urgent care by his friends after he started experiencing shortness of breath. She said that about a week before his becoming ill he had attended the Minnesota State Fair in late August and had contact with other people who were sick.Upon hospitalization, he was intubated and placed on high-frequency oscillatory ventilation, and his chest x-ray showed patchy ground-glass opacities. The patient had grossly bloody diarrhea from what physicians discovered was bowel ischemia.Though he received oseltamivir suspension though his nasogastric tube, his medical team didn’t note any improvement in his condition and suspected that the drug wasn’t being absorbed properly because of his gastrointestinal condition.Doctors assessed that the boy was experiencing systemic inflammatory response along with hypotension, pancytopenia, myocarditis, coagulopathy, acute renal failure with oliguria, hepatitis, and pancreatitis.Maroushek said doctors contacted the Minnesota Department of Health and the CDC to discuss IV antiviral treatment options and received emergency authorization to give the boy 600-milligram (mg) doses of IV peramivir for 5 days. Other treatment measures included norepinephrine, blood transfusions, and antibiotics for pneumonia.The patient improved 2 days after doctors initiated peramivir treatment. The boy did not develop a secondary bacterial infection. Though he was weak with symptoms of mental slowing at hospital discharge, she said the boy is improving with therapy and rehabilitation. His 25-day hospitalization cost about $300,000, she said.Oseltamivir-resistant caseIn the second case, Aditya Gaur, MD, an infectious disease specialist at St Jude’s Children’s Research Hospital in Memphis, Tenn., described a severe pandemic H1N1 infection a 10-year-old girl who was immunocompromised because she was undergoing treatment for leukemia.The patient was initially admitted to the hospital for 5 days with flu symptoms such as cough, runny nose, and fever. During hospitalization she received 150 mg of oseltamivir daily.In the 12 days after leaving the hospital the patient had mild residual symptoms, but her symptoms got worse and she was hospitalized again, this time with right lower-lobe pneumonia. Gaur said her respiratory status deteriorated and she was intubated and given broad-spectrum antibiotics. She also received oseltamivir through her nasogastric tube.The girl’s tracheal aspirates were positive for influenza A, and about a week later tests showed she had the oseltamivir-resistant H275Y mutation.Her medical team obtained an emergency investigational new drug clearance to give her IV zanamivir, 600 mg every 12 hours. Over the next 2 weeks the patient tolerated the drug well and her symptoms improved, Gaur said.Tim Uyeki, MD, a medical epidemiologist in CDC’s Influenza Division who moderated the clinician’s conference, commented that the child’s case pointed to evidence of prolonged viral shedding, which experts have documented in immunocompromised patients.Indications for IV antiviralsHayden said the two cases show value of IV antiviral treatment options for severely ill pandemic H1N1 patients. “We’ve known for some time the need for parenteral, rapid, and reliable delivery of these drugs,” he told clinicians.He said IV zanamivir can be life saving for patients who have oseltamivir-resistant viruses, especially when poor lung function precludes use of the powder or nebulizer version.Ribavirin is an older drug that has sporadically been used intravenously for severe flu patients and can be obtained on an emergency basis, Hayden said. “There’s not enough data on it, but if a patient is not responding to other antivirals, it can be used as a salvage drug,” he added.Physicians who use IV antivirals for critically ill patients should make sure therapy duration is sufficiently long, Hayden said, “It makes sense to push to at least 10 days,” he said, adding that immunocompromised patients may need the drugs for even longer.Hayden urged physicians to move quickly to IV antivirals when they encounter patients who are as severely ill as the two case study patients.Pavia agreed that early treatment is crucial. “To make the greatest difference, you need to shut off viral replication early, but it’s never too late to intervene,” he said.Some clinicians have used antiviral combination treatments that incorporate ribavirin, he said. However, he said the lack of data makes the strategy not an attractive option. “We’re very early in using combination treatment,” Pavia said.New drug in clinical trialsPavia and Hayden both mentioned a new antiviral drug that is in clinical trials, T-705, which is being developed by Toyama Chemical, a Japanese company. The new drug is not available yet for emergency use, but they urged physicians to be alert for any clinical trials of it that might be taking place near them.Today Fujifilm Holdings Corp, Toyama’s parent company, announced the launch of phase 3 clinical trials in Japan of T-705, a viral RNA polymerase inhibitor. The company said in a press release that phase 2 studies showed promising results as a treatment for seasonal flu and that animal studies have shown efficacy against the pandemic H1N1 virus.The company says because the drug’s mechanism of action is different than existing antivirals, it might provide an alternative treatment, especially given concerns about viruses developing resistance to neuraminidase inhibitors like oseltamivir, zanamivir, and peramivir.See also:Oct 29 Fujifilm Holdings press releaseOct 26 CIDRAP News story “Emergency authorization for peramivir draws fast response”
Otago Daily Times 20 Sept 2013A former Dunedin couple have regained custody of their daughter after two years, following a High Court decision overturning a care and protection order.Justice Graham Panckhurst has ruled it was ”very unlikely” the parents deliberately inflicted the then 8-month-old’s injuries.The couple, whose names are suppressed, lived in Dunedin when their baby was put into Child Youth and Family care after a hospital visit in July 2011 where she was found to has unexplained fractures.Removing child from parents defendedAfter a family court hearing in December 2011, Judge Stephen Coyle found the injuries to be non-accidental, based on the specialist medical evidence given, and inflicted by her parents, despite ”a lack of evidence to suggest either were anything other than caring parents”.Guardianship of the baby was awarded to a family member in the North Island and the parents given access. The parents then sold their house in Dunedin and moved to the North Island to be near their daughter.There was nothing to indicate a propensity to deliberately cause harm to their daughter. They had regular contact with friends, family and medical professionals so it was ”amazing” no sign of swelling, bruising or tenderness was observed, he said.http://www.odt.co.nz/news/dunedin/274021/parents-regain-custody-child
Convention attendee looks over Smith & Wesson pistols at NRA meeting.Some say it will be the largest convention in state history.The National Rifle Association is coming to Indiana in April, and officials believe it could draw crowds of up to 77,000 people and have an economic impact of $55 million.The city began working with the NRA several years ago to bring the convention to the state, which will feature more than 600 exhibitors, seminars and celebrity appearances.The convention will put the city into the national spotlight, and officials in Indianapolis say they are also prepared to handle the likely draw of protestors.The NRA Convention is set for Apr. 25-27.
The Jac-Cen-Del Lady Eagles defeated The Milan Lady Indians in Varsity Volleyball Action 25-20, 25-20, 25-19.Courtesy of Eagles Coach Shelli Voss.
Press Association Four goals in six matches suggest he has enjoyed starting as a central striker under Arsene Wenger and Bruce is unsurprised. “I rang his brother (and agent, Chris) but there was some rather big clubs in for him,” said Bruce, whose side take on the Gunners at the Emirates Stadium on Saturday. “I think Spurs were in there, Arsenal as well of course, and one or two from Europe as well. “He had a pick shall we say but, yes, we had a dabble. “I’ve got no doubt in my mind after working with him that he can play at any top four side, no question. He’s a top player. “He’s played a lot on the left (for United) and then people start criticising his goalscoring record, but you put him down the middle as a striker and he will score.” Bruce, as a former Red Devils captain, was surprised to see his old club cash in on one of their brightest homegrown talents but understands the dilemma Louis van Gaal faced balancing his forward options. “They’ve made changes at United and decided he’s surplus but I believe he can play in any top team around Europe,” said Bruce. “When you’ve got (Wayne) Rooney, (Robin) van Persie and (Radamel) Falcao you’ve got a decision to make but it surprised me because not often do you see Manchester United selling a very good young player. “The proof will come over time whether they regret it but I’m sure it will work out for him at Arsenal.” Steve Bruce has revealed he tried to sign Danny Welbeck for Hull in the summer, but has no doubt he has the class to thrive at the very highest level with Arsenal. Tigers boss Bruce has history with the England striker, having taken him to Sunderland on loan in 2010-11, and was keen to renew their acquaintance when it became clear Welbeck’s Manchester United days were numbered. He admits Hull’s interest never got past an initial enquiry, with heavyweight suitors from home and abroad vying for the 23-year-old’s signature, and accepts the player deserves to be among the Champions League elite.
Moscow, July 12: Although England lost the semi-final to Croatia in the FIFA World Cup, “the whole thing is beyond where we thought we might go”, coach Gareth Southgate has said.A superb Kieran Trippier free kick gave England an early lead in their semifinal against Croatia on Wednesday before Ivan Perisic equalised with a 68th minute volley.Mario Mandzukic then secured his team a place in Sunday’s final against France by netting in the 19th minute of extra time.“We’ve come an incredibly long way in a short space of time,” Southgate said after the match.“The whole thing is beyond where we thought we might go. Tonight we weren’t quite there. But the team will be stronger for it.“We want to be a team who are hitting quarter-finals, semi-finals and finals. That’s what we aimed to do in the long-term. We’ve proved to ourselves and our country that is possible.“Now we have a new benchmark, a new level of expectation, a new scenario. But many of these players have come of age on an international stage. I couldn’t be prouder with what they’ve done. For everybody in our party, I wanted them to create memories that are with them forever, for them and for others. If we’ve brought joy back home, which I know we have, then that’s been worthwhile. We should be proud of that.” IANS
Westbrook tests positiveLAKE BUENA VISTA, Fla. (AP) — Russell Westbrook of the Houston Rockets says he has tested positive for coronavirus, and that he plans to eventually join his team at the restart of the NBA season. Westbrook made the revelation Monday on social media. As recently as Sunday, the Rockets believed that Westbrook and James Harden — neither of whom traveled with the team to Walt Disney World near Orlando last week — would be with the team in the next few days. In Westbrook’s case, that now seems most unlikely.NFL-LIONS-OKUDA Braves say they won’t change name but studying chop chantATLANTA (AP) — The Atlanta Braves say they have no plans to follow the lead of the NFL’s Washington Redskins and change their team name. The tomahawk chop chant used by Braves fans is under review, however. The team said in the letter it is seeking input from the Native American community, fans, players and former players as it examines the fan experience, including the chant. The Redskins announced Monday they will change their name and Indian head logo.The Braves say they have established a “cultural working relationship” with the Eastern Band of Cherokee Indians in North Carolina and formed a Native American Working Group. The name came with the team on its move from Milwaukee to Atlanta in 1966. The name was adopted in 1912, when the team was based in Boston. MLB-BASEBALL ROUNDUPMajor league teams try to ramp up the competition in campUNDATED (AP) — Major league teams are working out in mostly empty ballparks, mindful the long-awaited start to the season is barely a week away and fans won’t be coming. So teams are trying as best they can to ramp up the competitiveness of summer camps conducted in isolation. Several teams announced upcoming exhibition games, including Houston at Kansas City, Kansas City at St. Louis, and Cleveland against Pittsburgh. The Milwaukee Brewers will play intrasquad games for several nights starting Tuesday and are dubbing them the Blue and Gold World Series, a nod to manager Craig Counsell’s alma mater, Notre Dame. VIRUS OUTBREAK-NBA Hicks opts out of 2020 seasonST. LOUIS (AP) — Hard-throwing St. Louis Cardinals reliever Jordan Hicks has opted out of playing this season, citing pre-existing health concerns. The 23-year-old Hicks was diagnosed in high school as having Type 1 diabetes. Hicks, who routinely throws over 100 mph, is recovering from Tommy John surgery on June 26, 2019. The right-hander’s availability for this season was uncertain. Hicks had been taking part in workouts at Busch Stadium, leading up to the Cardinals’ opener on July 24 at home against Pittsburgh.VIRUS OUTBREAK-NHL Update on the latest sports The face shield was designed by Oakley, which already provides visors for the players. The union’s medical director had suggested that players wear face masks to help control the spread of the virus, but players shot down that idea. The face shield has received a better response than the mask suggestion.VIRUS OUTBREAK-CHICAGO MARATHONChicago marathon canceledCHICAGO (AP) — The Bank of America Chicago Marathon has been cancelled due to the coronavirus pandemic. Share This StoryFacebookTwitteremailPrintLinkedinRedditREDSKINS-NICKNAMEWashington NFL team dropping ‘Redskins’ name after 87 yearsWASHINGTON (AP) — The Washington NFL team is shedding the “Redskins” name effective immediately. July 13, 2020 In other developments:—The Patriot League has joined the Ivy League and called off fall sports because of the pandemic. The league’s 10 Division I schools will not compete this fall in football, soccer and women’s volleyball. The Ivy League announced a similar decision last week. VIRUS OUTBREAK-NFL-FACE SHIELDSNFL comes up with face shields for helmetsUNDATED (AP) — With NFL training camps set to start at the end of the month, the league believes it is one step closer to addressing player safety amid the coronavirus pandemic. It has come up with face shields for the players’ helmets. NHL says 43 tested positiveUNDATED (AP) — The NHL says 43 players tested positive for the coronavirus from June 8 through the end of the league’s optional workouts.That number announced Monday includes 30 who tested positive at team facilities and 13 the league is aware of who tested positive outside the league’s protocols for its Phase 2.The NHL opened Phase 3 Monday with the start of training camps for the 24-team playoffs, scheduled to open in two hub Canadian cities — Toronto and Edmonton, Alberta — on Aug. 1. Players had until Monday evening to elect to opt out of competition without penalty.All players who tested positive self-isolated. The NHL is not sharing names of the players who test positive or the teams involved. Lions sign 1st-round pick Okudah, Swift, Cephus, Huntley’ALLEN PARK, Mich. (AP) — The Detroit Lions have signed first-round pick Jeff Okudah.The Lions also announced Monday that they signed second-round selection D’Andre Swift along with fifth-round picks Quintez Cephus and Jason Huntley.Detroit drafted Okudah, a former Ohio State standout, with third overall pick and made him the highest-drafted cornerback since Shawn Springs was selected from the same school by Seattle in 1997. The Lions are hoping he becomes a game-changing talent to help a defense that ranked No. 31 in the league last season.LAKERS-RONDO INJURED Lakers G Rajon Rondo breaks thumb in practice, out 6-8 weeksLOS ANGELES (AP) — Rajon Rondo has broken his right thumb in practice with the Los Angeles Lakers in Orlando. The veteran point guard will be out for six to eight weeks. Rondo has been a key backup during his second season with the Lakers, who signed him shortly after adding LeBron James to the roster in July 2018. Rondo is averaging 7.1 points, 5.0 assists and 3.0 rebounds in 48 appearances this season, including three starts. He has been a regular presence on the floor late in close games, with coach Frank Vogel trusting his veteran leadership and playmaking.MLB-CARDINALS-HICKS VIRUS OUTBREAK-COLLEGE SPORTSSEC weighs football seasonUNDATED (AP) — Southeastern Conference athletic directors met in person Monday at league headquarters in Alabama to discuss the prospects for a football season with COVID-19 cases spiking throughout much of the South.SEC Commissioner Greg Sankey said in a statement afterward that it’s “clear that current circumstances related to COVID-19 must improve.” The Big Ten and Pac-12 have said they would only play conference schedules this fall in football and other sports. Sankey said SEC leaders “believe that late July will provide the best clarity for making the important decisions ahead of us.” The group met in the large Kramer-Moore Conference room to allow for social distancing. Other groups and individuals participated by videoconference.Among topics discussed were possible scheduling options for holding athletic competition this fall, along with game management at events. The change comes less than two weeks after owner Dan Snyder launched an organizational review amid pressure from sponsors to make a change. FedEx, Nike, Pepsi and Bank of America all lined up against the name, which was given to the franchise in 1933 when the team was still based in Boston.A new name for one of football’s oldest franchises must still be selected and it’s unclear how soon that will happen. Native American experts and advocates have long protested the name they call a “dictionary-defined racial slur.” More than a dozen Native leaders and organizations wrote to NFL Commissioner Roger Goodell last week demanding an immediate end to Washington’s use of the name.Goodell, who has fielded questions on the topic for years, said he supported the review. BRAVES-NICKNBAMES Associated Press In a statement Monday, marathon organizers and city officials cited the challenge of staging the large-scale Oct. 11 event while COVID-19 concerns endure. As of Sunday, Chicago’s health department reported 55,184 confirmed cases of the virus and 2,682 deaths due to complications from COVID-19. Chicago’s event typically draws about 45,000 runners and wheelchair athletes, and more than one million spectators. Mayor Lori Lightfoot says she is personally disappointed at the cancellation. The Boston Marathon and New York Marathon have also been canceled because of the pandemic.
Pre-health students will gather for a conference on Sunday to discuss global health care issues and how they affect different aspects of the medical field.The Alpha Epsilon Delta pre-medical honors society will host its annual Southland Pre-Health Conference, featuring a keynote speaker from the USC Institute for Global Health. The conference is held annually to educate pre-health undergraduates about the medical field.“The way we want to relate global health things is that we want to give a perspective of health as a whole in the entire world. But at the same time, we want to compare that to our health care system here,” Southland co-chair David Daar said.Keynote speaker Dr. Jonathan Samet, director of the Institute for Global Health, was asked to speak because he represents the focus of the conference: global health care.AED chose to focus on global health care because of rising student interest in wanting to practice medicine outside of the United States.“A lot of our members are interested in the [World Health Organization] or the doctors without borders,” Daar said.Daar and co-chair Emma McDonnell said this year’s conference will be different from previous ones because it will span many different facets of medicine.“Our variety of speakers is definitely different. We tried to pull in people from all facets of health care or physical therapists or physician assistants,” McDonnell said.McDonnell added that AED collaborated with pre-pharmacy students this year, something they’ve never done before.The conference will also feature Gina Camello, associate director of admissions at the USC Keck School of Medicine, who will talk to students about applying to medical school.Although health care reform will not be a main focus, organizers said they have asked many of the medical experts to touch on the potential health care changes.“We’ve asked our individual speakers to talk about how the health care reform will affect them personally,” McDonnell said.Along with speakers and workshops, the test-prep company Princeton Review will be hosting a raffle for two $1,000 scholarships for MCAT prep classes. One scholarship is enough to cover half the price of a standard course. Kaplan will also have representatives at the conference.The focus of the conference is not admissions, though, Daar said. Instead, AED hopes to give attendees a picture of health care today and a sense of what their careers might be like.“It’s for students by students,” he said.This is the 44th Southland conference at USC, but AED has only recently started hosting the event at the Davidson Conference Center, McDonnell said.The majority of the cost of holding the conference is renting the Davidson center, according to McDonnell. AED received funding from the Undergraduate Student Government, as well as the Office of the Provost, through support from Vice Provost for Undergraduate Programs Gene Bickers.“We got $2,000 after presenting to the professional fund at USG,” McDonnell said. “We also got shirts donated from the bookstore as part of the thank you packages we’re giving to [the speakers].”Jeff Sakamoto, a freshman majoring in biomedical engineering, said he would consider going to the pre-health conference to explore his options. For now, Sakamoto said, he wants to go into the medical field, but he’s not sure what aspect he wants to focus on.“I would go to get more of a broader view on medicine — I mean, medicine is such a huge field — just to see what I’d be interested in doing because there’s so much that you can do in medicine,” Sakamoto said.
However, when 29% of eligible voters vote, the foundations of our American democracy crumble. 29 % means that over two-thirds of the electorate’s voices were not heard. It means that hundreds of thousands of citizens did not possess the means, will or desire to vote, which becomes especially worrisome when the issues those citizens have the opportunity to affect are not passing yards and points allowed, but health care and climate change. One day after the Super Bowl, the Iowa caucuses began. From what I understand, it’s an event where a bunch of politically active Iowans take work off to assemble in gymnasiums, churches, libraries and homes throughout the state to duke it out and pick the candidate they want to represent their party in the general election. Patrick Mahomes and the Kansas City Chiefs had the attention of 102 million Americans at Super Bowl LIV. (Photo via Patrick Mahomes / Twitter) We can draw several conclusions from this feeling of existential sports dread. First, I should get out more, and second, sports are very important in the United States — so important that some have gone as far as to call it “America’s religion.” In comparison, a 2014 poll conducted by the Associated Press and GfK Public Affairs and Corporate Communications found that there were about 160 million NFL fans in America. When Super Bowl LIV’s viewership is taken into account, that means 63% of fans tuned in to watch the game. “The sports stadium has replaced the church sanctuary as the dominant arena of piety at the turn of the 21st century,” wrote professor and theologian Randall Balmer in an article for Sojourners. Could you imagine if a three-day delay had befallen the Superbowl? Even a 30-minute delay would have drawn the unquenchable outrage of fans and corporate sponsors alike. Stuart Carson is a junior writing about the intersection of sports, politics and American society. He is also a sports editor at the Daily Trojan. His column, “The State of Play,” runs every other Wednesday. How this plays out in reality is still hazy to me no matter how many articles I read online, but the big takeaway is that these caucuses have correctly picked the Democratic Party’s eventual nominee 100% of the time over the past five election cycles. So, they’re very important. In Iowa, complications with an app designed to deliver caucus results to the state Democratic Party led to a politically apocalyptic meltdown where election results that were supposed to arrive by the end of the night took an additional three days. Unfortunately, unlike Super Bowl LIV, where the NFL orchestrated a flawless halftime show and succeeded in making droves of straight white males feel like strong, independent Latinx women, the Iowa caucuses were a disaster. In light of America’s current state of political participation, this is deeply discouraging. Through both qualitative and quantitative lenses, we appear to be a country more invested in professional sports than our democratic processes. And while I recognize that it is easier to take in the joys of a football game than it is to vote, the idea that we are collectively more concerned with the fate of the Kansas City Chiefs than the fate of the United States is alarming. Last weekend marked the beginning of what many American sports fans consider to be the worst part of the year — a miserable stretch of time between the end of the Super Bowl and the beginning of March Madness where all we have left to watch is NBA games where players clearly do not care enough yet to try and NHL games that no one within 50 square miles of you is aware of. The numbers back up Balmer’s claim as well. A week and a half ago, 99.9 million viewers tuned in to watch Super Bowl LIV. This represented a slight uptick from the previous year: Super Bowl LIII garnered 98.2 million. To add icing to the cake, when factoring in the use of streaming platforms, Super Bowl LIV’s viewership increases to 102 million people. I recognize that in real life, explanations for both events and their outcomes are more complicated than I have given them credit for. Democracy is a hairy, messy affair, and far more barriers to entry exist for voting than for watching the Super Bowl. But am I alone in thinking to myself that this 34-point discrepancy is terrifying? If 29% of football fans were to watch the Super Bowl, life would continue as it always had. The Chiefs would have still won the Super Bowl, Jimmy Garoppolo would still have choked, and you still would have gone to work or class the next day. Gone are the weekends of watching football and the weekdays of watching football highlights. Now, for approximately one month, sports fans are left to lie alone and idle, reminiscing over the once-constant stream of football that now feels like a distant memory. It is disheartening when the passion of NFL fans exceeds the political participation of the American populace. In democracy, participation doesn’t determine the winner of a game but the fate of an entire nation. Unfortunately for our country, attendance is lacking. What’s more is that turnout at the Iowa caucuses fell well below expectations. Only 176,000 out of 616,000 actively registered Democrats in Iowa participated in the caucuses. That is a 29% participation rate.
First Published: 23rd August, 2020 14:30 IST LIVE TV COMMENT SUBSCRIBE TO US Associated Press Television News Written By WATCH US LIVE Last Updated: 23rd August, 2020 14:30 IST Syme, Soderberg Share Lead At European Tour’s Wales Open Connor Syme of Scotland and Sebastian Soderberg of Sweden were tied for the lead — three shots clear of the field — after the third round of the European Tour’s Wales Open on Saturday Connor Syme of Scotland and Sebastian Soderberg of Sweden were tied for the lead — three shots clear of the field — after the third round of the European Tour’s Wales Open on Saturday.Syme, seeking his first professional title, birdied the last hole for the third time this week to shoot a 1-under-par 70 and join Soderberg on 7 under overall.Soderberg had already signed for a bogey-free 68 as he searches for his second victory on the tour, after the European Masters last year.Syme was leading by two shots after the second round.Sami Valimaki of Finland is third after a 67, the best round of the day.Edoardo Molinari (68) and Thomas Pieters (69) were a shot further back at Celtic Manor, which was also the host of last week’s Celtic Classic.Sam Horsfield slipped away in his bid for a third win in four starts. The English golfer struggled to a 77 and was in 75th place at 8 over. FOLLOW US